Several factors influence the calorie count in a cup of coffee with milk and sugar, including:

1. Type of Milk: Whole milk, skim milk, almond milk, and other alternatives have different calorie contents. For instance, whole milk has more calories than skim milk.

2. Amount of Sugar: The quantity of sugar added directly affects the calorie count. Using less sugar or sugar substitutes can significantly reduce calories.

3. Serving Size: The size of the coffee cup also plays a role; larger servings will naturally contain more calories if more milk and sugar are added.

4. Additional Ingredients: Any extra ingredients, such as flavored syrups or whipped cream, will contribute additional calories.

A standard coffee with milk and sugar contains about 70 calories.